Ribosomal Transcriptome
Ribosomes are complexes of RNA and protein. Ribosomes are large molecular machines that translate sequences of messenger RNA into proteins in all living cells. Furthermore, there is a close correlation between ribosome biogenesis and cell proliferation.
Full Description
There is increasing evidence that dysregulated ribosome biosynthesis is closely associated with an increased risk of cancer and metabolic disorders. Analysis of ribosomes has identified some of the factors involved in these complex processes, providing new perspectives for further in-depth study of ribosome properties and functions.
Ribosomal Transcriptome
Both biological sciences and medicine rely on rapid genomic and transcriptomic analysis techniques to probe cellular state, physiology, and activity. Among the technologies, microarray technology and next-generation transcript sequencing (RNA-Seq) are the most advanced. Among them, RNA-Seq offers limitless possibilities in modern biological analysis. For the ribosomal transcriptome, the analysis mainly involves cDNA libraries from short mRNA fragments covered by ribosomes.
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